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Top 13 Best Immune Booster Supplements to Support Immunity

Our body’s immune system fights against infections, viruses, bacteria, foreign bodies, and various diseases. The organs which make up our immune system are the thymus, lymph nodes, and bone marrow.

Some people have good natural immunity, while others adopt a good diet and healthy lifestyle to make their immunity strong. You must have heard that vitamin C, fruits, vegetables, zinc, and some other compounds boost our immunity, and we should include these ingredients in our diet.

Moreover, hundreds of supplements claim to boost our immunity and protect us against infectious diseases but are all these claims valid?

No, unfortunately, many of these supplements are ineffective.

13 Best Immunity Supplements

Out of hundreds of immunity boosters available in the market, we have formulated a list of the most effective and safe immunity boosters.

These supplements are ranked based on various ranking factors such as science-backed ingredients, dosages, manufacturer reputation, and advertised benefits.

  • VitaPost’s Immune Support
  • Mushroom Defense
  • Zenith Labs Nano C
  • VitaPost Immune Complex
  • Epishield Plus
  • Advanced Bionutritional’s Resistol
  • Organixx 7M
  • BioShield MD
  • VitaPost’s Turmeric & Ginger
  • Jay Lab Pro’s Immune Defense 4x
  • Doctor G’s Naturals Q-Ion Immune Defense
  • PhytAge Labs Immunity 911
  • Immunity Formulas Immune Support

Let’s get into the details of each immunity booster on our list!

VitaPost Immune Support

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The VitaPost Immune Support contains many natural ingredients: vitamin E, green tea extract, Graviola leaf, beta-glucans, and mushrooms. Some of these ingredients are antioxidants that fight against free radicals. In contrast, other elements are associated with a healthy immune system in aged people.

It is one of the best immunity boosters available in 2021, as it also offers a good value for the money.

Mushroom Defense

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Mushrooms, a popular ingredient that we use in daily life, are surprisingly good for boosting immunity. It fights against fatigue and cognitive decline. It also sharpens your memory and helps to stay focused.

The Mushroom Defense supplement contains ten unique mushroom extracts, including Agaricus blazei, Turkey tail, Lion’s mane, Chaga, Shiitake, Maitake, and Cordyceps Sinensis. The company claims that their supplement provides powerful antioxidants, increases energy, promotes rapid defense response, and improves overall wellbeing. It also offers a 67 days refund policy.

Zenith Labs Nano C

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Nano C from Zenith Labs is a vitamin C supplement. This supplement created by Dr. Ryan Shelton gives a bioavailable version of vitamin C to your body. It is available in the form of a tincture; you must take two to three drops daily to boost your immunity.

The unique part of Nano C is that it gives you a 1000 times smaller amount of vitamin C than other supplements in this list. But it is absorbed readily and efficiently into your bloodstream. The company claims that this supplement will fuel up your body with antibodies, help you recover from viruses and bacteria, and support your immune system.

VitaPost Immune Complex

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VitaPost Immune Complex is another affordable immunity booster on our list. It is unique as it contains elderberry, Echinacea, and probiotics. The probiotics in VitaPost Immune Complex support beneficial bacteria in your gut and support the immune system.

Elderberry and Echinacea in this supplement reduce flu and cold symptoms. Along with the above ingredients, the immune Complex also includes vitamins, zinc, botanicals, and turmeric; that flood your body with antioxidants.

Epishield Plus

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Epishield Plus is a dietary supplement that contains vitamin C, vitamin D, and mushroom extract. It also includes a unique ingredient, fermented yeast, that is not found in other supplements. This yeast EpiCor is derived from saccharomyces Cerevisiae boosts your immune system.

Simple Promise Epishield Plus claims to support your immunity within two hours of intake. The website shows that the product is out of stock because of high demand.

Advanced Bionutritionals Resistol

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Advanced Bionutritionals Resistol is a secret cold remedy used by celebrities to keep their immunity strong. The Resistol supplement contains five unique herbs not found in other supplements on this list; Andrographis, Eleuthero, Platycodon, licorice, and Prickly chaff flower.

Andrographis in this supplement provides antibacterial and antiviral effects. It also boosts white blood cell counts to boost your immune system. The company also offers you zero risk purchase and a 90-day money-back guarantee.

Organixx 7M

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Organixx 7M contains shiitake mushroom extract, reishi mushroom extract, and maitake mushroom extract. These three mushroom extracts are robust and have scientifically proven effects on immunity. The formula also contains beta-glucans that are known for their antioxidant and anti-inflammatory properties.

Furthermore, you will also get cordyceps, turkey tail, and lions mane mushroom extract from this supplement. The Organixx 7M supplement makers claim that it fights against indigestion and protects from aches and pain.

BioShield MD

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BioShield MD is one of the immune boosters that give you essential ingredients at clinically effective dosages. This supplement is a doctor’s formulated supplement formed by Dr. Mark Rosenberg of sun coast sciences. He has added science-backed ingredients to support the immune system, increase energy levels in the body, improve mental health and treat joint pain.

Some of the ingredients included in BioShield MD are resveratrol, curcumin, tart cherry extract, quercetin, Boswellia Serrata, cocoa extract, and green tea extract. These ingredients fuel your body with antioxidants and flavonoids that boost immunity in multiple ways. Also, it protects the neurons, reduces anxiety, and promotes positive feelings and calmness. Take two capsules per day for long-term beneficial effects.

VitaPost Turmeric & Ginger

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VitaPost Turmeric & Ginger is a superfood blend of famous culinary roots, ginger, turmeric, and Bioperine. Bioperine increases the bioavailability and absorption of essential nutrients. Turmeric has proven benefits and has been used in Ayurvedic medicines for centuries; it promotes respiratory system health, joint health, wakefulness, and anti-inflammatory.

Moreover, VitaPost Turmeric & Ginger is FDA approved and meets GMP standards. You must take one capsule twice daily to experience its beneficial effects. This capsule is suitable for you if you are looking for a naturally effective supplement for your immune system.

Jay Lab Pro Immune Defense 4x

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Immune Defense 4x is one of the supplements that offer effective ingredients in potent dosages. It gives you 500 mg of EpiCor, 500 mg of quercetin, 150 mg bromelain, and 166% DV vitamin D.

The EpiCor, an extract of dried yeast added in this supplement, is famous for supporting immune functions. Furthermore, with the purchase of JayLab Pro Immune Defense 4x, you will also get an immunity-boosting support playbook. The book contains various recipes to supercharge your immune system, along with a sample weekly meal plan. You also get a 60-day money-back guarantee, so if you aren’t satisfied with the product, you can get your refund back.

Doctor G’s Naturals Q-Ion Immune Defense

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Doctor G’s Naturals Q-Ion Immune Defense formula results from the medical expertise and experience of Dr. John Gordon. The formula contains essential ingredients such as quercetin, green tea extract, Camellia Sinensis Extract, zinc, and bromelain.

Moreover, this innovative supplement is based on Ion Blast Technology, which increases the bioavailability and absorption of quercetin and zinc in the body. It claims to offer anti-inflammatory and antiviral effects along with promoting better immunity. No doubt it is one of the expensive formulas on this list.

PhytAge Labs Immunity 911

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PhytAge Labs Immunity 911 is a powerful fusion of the world’s best immunity-boosting ingredients. It is GMP-certified, GMO-Free, gluten-free, and dairy-free safe supplement to fight against dangerous viruses.

Some of the groundbreaking ingredients in Immunity 911 are Graviola leaf, Himalayan raspberry, pomegranate, olive leaf, and mushroom. In addition, these unique ingredients also contain turmeric, pine bark, burdock, sheep sorrel, grape seed extract, cat’s claw, and garlic. Due to the combination of many effective and scientifically proven ingredients, it is effective in fighting against all kinds of infections and supporting the immune system.

Immunity Formulas Immune Support

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Immunity Formulas Immune Support is a combination of therapeutic herbal essential oils. According to the company, this formula can fight against all viruses, and bacteria, boost your immune system, promote the natural defense mechanism of the body, sanitize all surfaces, and disinfect and purify the surrounding air.

Some of the essential oils in the Immune Support formula are lemon, peppermint, turmeric, oregano, and cinnamon. It is also GMP certified, and lab tested.

How We Rank The Best Immunity Supplements

Immunity boosters are in demand today more than ever before, and there are hundreds of supplements to support your immune system. All these immunity-boosting supplements claim to fight against infections and help your immunity. But are all these supplements worth spending money on? No, because not all supplements contain science-backed ingredients in recommended dosages.

We know it is challenging to find the best supplement for your immune system; therefore, we have prepared a list of the best immunity boosting supplements based on the following ranking factors:

Science-Backed Ingredients

According to scientific research and clinical trials there are various ingredients effective for supporting the immune system, such as zinc, vitamin C, vitamin D, elderberry extract, and probiotics. We rank those supplements that include effective ingredients for immune support.

Effective Dosages

Ingredients are only effective when added in standard dosages. If supplements contain less dosage, they are ineffective. We include those medications in our list that have the clinically proven recommended dosages of ingredients as it increases the efficiency and safety of the supplement.

Company Transparency And Reputation

Checking manufacturer reputation is one of the most vital ranking factors. Some manufacturers have a long-standing record of producing high-quality supplements, while others make dangerous supplements to earn money.

We include those transparent companies in disclosing ingredients, benefits, dosages, and side effects of the product. Also, the companies with a long-standing record of producing clinically effective supplements are on our list of the best immunity-boosting supplements.

Honest Advertised Benefits

Many companies claim to provide unrealistic benefits such as treating diseases, preventing COVID-19, and others. In contrast, other companies market their products with tangible benefits they offer. We rank the companies that advertise actual benefits and are effective in boosting your immune system.

Medical Advisory Board

Some supplement manufacturing companies invest in their medical advisory board. They use the expertise and experience of doctors in manufacturing the best immunity boosters. Suppose certified doctors, nutritionists, or other medical professionals are on the medical advisory board. In that case, we consider those products as reliable and include them in our list of the best immunity-boosting supplements.

Cost-Effective Supplements

We include those supplements in our list that are budget-friendly and offer good value of money. You will get the immunity booster in your budget whether you want to spend a few dollars or hundred dollars and all these supplements offer a good value for their price.

Source Of Ingredients

A few companies source their ingredients from cheap and non-registered facilities. However, others source the ingredients from FDA-approved and certified locations. We rank the supplements containing high-quality ingredients sourced from reputable suppliers to ensure their efficiency and safety.

The Benefits Of Immunity boosters – According To Scientific Evidence

A robust immune system is crucial for health and wellness. Your immune system fights against bacteria, viruses, infections, and other diseases. Even you have decrease chances of getting COVID-19 if your immunity is strong.

Science suggests the benefits of natural herbal extracts, zinc, vitamin D, vitamin C, mushrooms extracts, and other nutrients in supporting your immune function. Thus, it is essential to have a balanced diet full of essential nutrients and vitamins.

Consuming a balanced diet, getting proper sleep each day, drinking water, and some lifestyle modifications can support your immunity.

On the other hand, smoking, drinking alcohol, eating fast food, poor sleeping habits, dehydration, stress, and lack of physical exercise are some of the factors that weaken your immune system.

Numerous researches suggest that one of the essential vitamins that help boost immunity is Vitamin C. As per the National Institutes of Health, vitamin C helps in protein synthesis and collagen synthesis, wound healing, and is an antioxidant that fights against free radicals. Vitamin C also prevents and treats cancer, reduces the risk of cardiovascular disease, age-related macular disease, and cataracts. Many of the immunity-boosting supplements in our list contain vitamin C.

Another essential ingredient for the immune system is Vitamin D. Studies suggest that people who take recommended daily doses of vitamin D have better immune function than those who lack vitamin D. A study in 2011 suggests that vitamin D deficiency leads to increase autoimmunity and risk of infections. This study also indicates the role of vitamin D on the innate immune system. You can get vitamin D from various foods such as dairy products or through the skin from sunlight.

Protein is a vital nutrient for supporting the immune system. You won’t get protein from any of the best immunity-boosting supplements; however, you can get it through eggs, yogurt, beef, pork, fish, beans, nuts, poultry, and soy products. Protein is a combination of multiple amino acids that act as fuel for your immune system. Studies suggest the effect of amino acids in optimizing the immune functions of gut and proximal immune cells.

Many immunity boosters contain zinc, or you can get zinc from various foods such as nuts, oysters, meat, or whole grains. Studies suggest that zinc deficiency leads to an increased risk of infections and immune dysfunction. Zinc is well known for its antioxidant and anti-inflammatory effects.

Your gut health correlates directly to your immune system. If you have an excellent digestive system, your body performs well, and your immune system is healthy. Probiotic supplements support your digestive system bacteria and improve gut health. A study also shows probiotics as beneficial in preventing and treating allergies. Another study links probiotics for the treatment of immune-related disease and viral infections.

Elderberry is an unpopular ingredient; however, it has treated cold and flu in some areas for centuries. Today with the growing demand, many companies add elderberry extract in various supplements, including immune boosters. A study proves that elderberry is rich in vitamin C, which makes it a powerful immunity booster. Another study suggests elderberry extract as an efficient, safe, and cost-effective solution for influenza A and B symptoms.

Echinacea is one of the ingredients to support immune function when consumed at the onset of symptoms. It appears ineffective if used at later stages. The research found that Echinacea reduces the severity and duration of upper respiratory infections.

Ginger has been added to herbal medicine for centuries. Many supplements add ginger extracts because of their anti-inflammatory and antioxidant properties. This superfood also has proven benefits for supporting immunity.

Turmeric, a popular ingredient, is known for its anti-inflammatory and immunity-boosting properties. Turmeric contains curcuminoids such as curcumin that are associated with antioxidant properties. In a study, researchers found that turmeric activates multiple types of immune cells and supports immunity.

Some studies show that turmeric is poorly absorbed in the body; therefore, it is taken with black pepper extract (Bioperine), which increases its absorption and bioavailability by 2000%.

Overall, various studies and scientific research prove the efficiency of the above ingredients in boosting the immune system.

Are There Any Side Effects Of Immunity Boosters?

Most immunity-boosting supplements do not pose side effects if used at recommended dosages. Also, many supplements contain natural ingredients in the correct dosages that are safe for the body.

However, if you do not follow the dosage instructions of supplements, you may experience some side effects such as indigestion and bloat.

FDA has specific guidelines linked to the doses of ingredients. These doses are generally recognized as safe (GRAS) by the FDA. If the supplements contain GRAS ingredients, it does not possess adverse reactions.

If you are already taking any pill or have any comorbid conditions, you must consult your doctor before taking immunity-boosting supplements.

FAQs About Immunity Boosting Supplements

Q. What is an immune system?

A: The immune system of the body includes organs and processes that help to fight against infections and diseases. These organs include the thymus, lymph nodes, and bone marrow. When any foreign organism enters the body, our first line of defense responds and eliminates harmful pathogens.

Q. What are T cells?

A: T cells are the part of our immune system that fights against invading pathogens in two ways. The killer T cells directly destroy the infected cells, and the helper T cells activate B cells to produce antibodies against invading antigens.

Q. What are antibodies?

A: Antibodies are the protein produced by the immune system to target foreign antigens and destroy them.

Q. Which vitamins are best for boosting immunity?

A: Some of the most popular vitamins that support the immune system are vitamin C, Vitamin E, and Vitamin D. Numerous studies show the importance of these vitamins to boost immunity.

Q. What is innate immunity?

A: The first line of defense against outside substances is innate immunity. Your skin that prevents the microbes from entering the body, mucus that traps microorganisms, stomach acids that destroy microbes are the parts of our natural immune system. Your sweat and tears also contain enzymes that have antibacterial properties.

Q. What is acquired or adaptive immunity?

A: The parts of the body’s immune system that recognize foreign pathogens and create antibodies in response to these pathogens are included in acquired or adaptive immunity. Your spleen, bone marrow, thymus, and lymph nodes regulate this part of the immune system.

Q. What are some natural ingredients to support immune function?

A: The best foods to support the immune system are berries, elderberry extract, mushrooms, leafy greens, turmeric ginger, red grapes, dark chocolate, and citrus fruits.

Q. Which foods to avoid for immunity?

A: Studies suggest that the worst foods for our immune system are foods rich in sugar, junk food, fast food, refined carbohydrates ( bread, pasta, cakes, and cookies), processed meat, and foods with artificial trans fats. Therefore, you should avoid these foods to boost your immunity.

Q. Is obesity associated with a poor immune system?

A: Studies show that obese people have poor immune systems than those with a healthy weight.

Q. What are some natural ways to boost immunity?

A: You should adopt a healthy lifestyle and a balanced diet to support your immune system. Drinking enough water, getting good sleep, and doing daily exercise are some ways to strengthen the immune system.

Q. Which habits can hurt my immune system?

A: Smoking, excessive alcohol consumption, excess stress, poor sleeping habits, and an unhealthy diet weaken your immune system.

Q. Does age weakens the immune system?

A: With increasing age, your immunity gets weaker. Aged people have poor immune systems; therefore, they should adopt healthier lifestyles and nutritious foods to boost their immune systems.

Q. How is gut health associated with the immune system?

A: 70 to 80% of your immune cells are present in your gut. If you have a healthy digestive system, then your immunity will be stronger and vice versa. Many doctors recommend probiotics to support your gut health and improve immunity.

Q. Are immunity-boosting supplements beneficial and effective?

A: Most immunity-boosting supplements contain essential ingredients that have proven results to boost immunity. As per FDA, no supplement can claim to cure disease, improve health, or support immunity.

Q. Is exercise good or bad for boosting immunity?

A: Moderate exercise helps to improve the immune system. Moreover, exercise helps to maintain a healthy weight and prevent obesity. On the other hand, Strenuous exercise can reduce immunity if your body does not recover well after a workout.

Q. How Vitamin C helps in boosting immunity?

A: Vitamin C is an antioxidant that works against free radicals in your body. These free radicals are associated with diseases and illnesses. Studies also suggest the role of vitamin C in decreasing the duration of multiple conditions.

Q. What is the role of Vitamin D in boosting immunity?

A: Studies show that vitamin D modulates innate and adaptive immune responses. People with optimum vitamin D levels in the body have good immunity, while those with deficient Vitamin D have a poor immune system.

Q. What is the effect of Echinacea on the immune system?

A: Echinacea has been a popular ingredient to support immunity for centuries. Studies suggest that Echinacea is beneficial if taken at the onset of symptoms, not after the disease progresses.

Q. What is the role of probiotics on immunity?

A: Probiotics support gut health by feeding beneficial bacteria in your digestive tract. About 70 to 80% of immune cells are found in your gut; therefore, good gut health can help with better immunity.

Q. What is the role of zinc on immunity?

A: Zinc is a popular ingredient for the immune system. Consuming zinc can shorten the duration of symptoms.

Q. How does turmeric benefit immunity?

A: Turmeric is an antioxidant, popular as herbal medicine for centuries. Turmeric contains curcuminoids like curcumin that help to boost immunity. Turmeric is added to various supplements as a core ingredient to support immune function.

Q. How does elderberry benefit immunity?

A: Elderberry is popular in Europe as a traditional medicine for supporting immunity. It is a science-backed ingredient rich in vitamin C that helps to reduce the symptoms of cold and flu.

Q. How does garlic benefit immunity?

A: Garlic contains an active ingredient, allicin sativum, that has antibacterial and antiviral properties. Some studies suggest the significant effects of garlic in supporting the immune system.

Q. Does stress weakens the immune system?

A: Research shows that stress badly impacts the body’s natural defense mechanism. It also enhances the risk of cardiovascular problems and other diseases. Therefore, you should adopt ways to reduce stress to boost your immunity, such as meditation and sound sleep.

Q. Does germs make my immune system strong?

A: Germs help your body to adapt to foreign substances. Whenever a foreign pathogen enters the body, your body makes antibodies to fight against a pathogen. If the same microbe enters the body again, your body recognizes it and acts quickly.

Q. What are allergies?

A: Allergies are your body’s mistaken response against harmless substances such as dust, pollen, or a type of food. When the body detects these substances, it launches an immune response and causes allergies.

Q. What are autoimmune disorders?

A: When your body recognizes its tissues as foreign and attacks them, it is called autoimmunity. Some of the common autoimmune disorders are lupus erythematosus, multiple sclerosis, psoriasis, and rheumatoid arthritis.

Q. How do vaccines impact the immune system?

A: Vaccines activate the body’s immune system to produce antibodies against foreign substances. The vaccine does not infect your body with the disease but uses a unique component of the pathogen.

13 Best Immunity Supplements Final Thoughts

Immunity boosting supplements contain various essential ingredients beneficial for boosting the immune system, such as zinc, vitamins, herbal extracts, minerals, elderberry, and Echinacea.

Unfortunately, some supplements available in the market do not contain science-backed ingredients and are ineffective in boosting immunity. Therefore to help you pick the effective and safe immunity booster, we have made a list of the 13 best immunity-boosting supplements.

This list is based on essential factors such as science-backed ingredients, effective dosages, manufacturer reputation, cost-effectiveness, and honest advertised benefits.

Note that our immunity-boosting supplements list is not an alternative to medical advice and certified medical professionals. Make sure to talk to the physician before starting any medication. Each supplement works differently on every individual; therefore, you must check the pros and cons of each pill as per your health conditions. Also, note that this article is only for guiding you and helping you decide which supplement is best for you.

ALSO READ: Best Magnesium Supplements to Take: Top 17 Product Rankings

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The links contained in this product review may result in a small commission if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team and please know we only recommend high quality products.


Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.


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