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Top 30 Best Nootropics: Most Trusted Brain Booster Supplements of 2022

Whether you’re a student hoping to get good grades, an entrepreneur trying to maximize your profits, an employee seeking a promotion, or an older adult fretting about dementia, you can take brain-boosting supplements to enhance your cognitive function. Irrespective of what age group you belong to, nootropic supplements can improve your brain performance by boosting mental functions, i.e., memory, motivation, attention, creativity, etc.

Though the most recommended way to improve cognitive function is to make healthy lifestyle choices, i.e., adequate sleep, regular exercise, healthy diet, and stress management, nootropics add to healthy lifestyle choices.

The Top 33 Nootropic Brain Supplements For Better Mental Performance

With zillions of over-the-counter nootropic supplements available in the market, picking an effective and safe brain supplement to support your cognitive performance is not going to be a cinch for you. Therefore, our editorial team has prepared a list of the safest and most effective nootropic supplements available in the market to prepare the best nootropic stacks. The enumeration of the brain supplements or smart drugs in the list is not relevant to their quality or effectiveness.

Mind Lab Pro Unlocks 6 cognitive pathways to deliver best benefits
Brain C-13 The best solution to prevent abnormal changes in brain chemicals
Memo Defend A decent supplement for preventing memory loss in adults
MemoSurge A complete neurotransmitter-activating formula
Nootrogen A phenomenal nootropic formula to reduce stress and anxiety
PureHealth Research Ageless Brain The best vegan capsule to reverse brain-aging
Organixx Ageless Brain An evergreen formula for intense mental clarity
SANE Vitaae A clinically-approved product for fighting brain impairment
Onnit Alpha Brain A reliable product to restore memory and focus
Brain Boost One of the most premium herbal brain supplement
Performance Lab Mind A popular supplement to upgrade brain and nerve functions
Nuzena Neuro Focus + Assures optimal cognitive focus
NooBru A mouth-watering supplement to nourish brain and nerves
Hunter Focus A supplement that assures premium mental performance
BrainPill An all-round brain pill to make your brain more functional
OptiMind The only key to have a clean and sharp mind
Youthful Brain Promotes crystal clear thoughts to deliver best results
Mind & Mood A complete herbal adaptogenic formula for the brain
BrainEssence A doctor-approved complete brain care solution
Elm & Rye Nootropics A supplement known for elevating energy levels
Memory Hack An advanced cognitive support for all ages
Cymbiotika Golden Mind The only supplement rich in brain-friendly nutrients
Amy Myers MD NeuroLive A trustworthy supplement to offer effective mental clarity and focus
ReMind Solution Sure shot cognitive enhancement for all ages
Oweli Neuro The most-effective formula to unleash the max potential of your brain
ProMind Complex The only supplement to train your brain and nerves for complicated tasks and situations
NeuroGum A popular gum for enhancing neurological functions
Qualia Mind A consistent mental support supplement with long-term results
NeuroActiv6 A solution that better neural communications
Synapse XT A comprehensive therapy for forgetfulness
NooCube Brain Productivity Guaranteed memory retention is ensured by this brand
NeuroFuel A significant solution for brain cell regeneration
CogniBiotics Improves gut health to promote better brain functions

Here are the top 33 brain supplements available in the market:

Mind Lab Pro

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Mind Lab Pro is infused with 11 well-researched and clinically tested brain-boosting ingredients, one of the most famous brain supplements. This brain supplement also contains several patented and advanced nutrients, including NutriGenesis®, a blend of vitamins, minerals, and amino acids created by seeding live single-cell organisms with micronutrients in a hydroponic system to improve mental energy and mental performance.

NutriGenesis® aids in the absorption of other nutrients present in the nootropic formula by boosting their bioavailability.

This nootropic supplement is a bit expensive compared to most brain supplements on the list. Nonetheless, the potent cognitive function booster formula of Mind Lab Pro is worth the price. The Mind Lab Pro has no pointless or filler ingredients and is rated as one of the best nootropic formulas on the internet. It is a perfect introductory nootropic for people who are taking a brain-boosting supplement for the first time.

Mind Lab Pro was developed by Opti-Nutra, a health and wellness company led by competent neuroscientists. Dr. Ramon Velazquex Ph.D. serves as the head of the medical advisory board of Mind Lab.

Formulation Capsules
Ingredients Mannan, Beta-1, 3-glucans, GPx4 (glutathione), Superoxide Dismutase, Digestive-supportive, Prebiotics, Probiotics, Citicoline, Lion’s Mane Mushroom, Rhodiola Rosea extract, Phosphatidylserine, Bacopa Monnier
Side effects No side effects
Price $69
Dosage 2 capsules daily
Money-back guarantee 30-day money-back guarantee

Brain C-13

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Developed by Zenith Labs, Brain C-13 is a brain-boosting nutritional supplement replete with essential minerals, vitamins, and plant and herbal extracts that synergistically inhibit age-related cognitive decline and improve brain performance.

The formula of Brain C-13 is designed under the supervision of Dr. Ryan Shelton, medical research director at Zenith Labs. Brain C-13 boosts your cognition by inhibiting age-related or abnormal changes in the chemical composition of your brain, thereby mitigating the chances of cognitive decline. The supplement is highly beneficial for people above 40 years of age. It is manufactured in an FDA-regulated GMP-certified facility and is one of the safest products on the list.

Formulation Capsules
Ingredients Dimethylethanolamine (DMAE), Rhodiola root extract, Turmeric, Huperzine A, Phosphatidylserine, Mucuna pruriens, Rosemary leaf, Centella Asiatica, Sarcosine, Acetyl-l-carnitine, Magnesium l-threonate, Vinpocetine, CDP-choline
Side effects No side effects
Price $49
Dosage 3 capsules daily
Money-back guarantee 180-day money-back guarantee

Memo Defend

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Developed by a researcher named Thomas Taylor, Memo Defend is a brain pill that supports your mental function by reversing memory loss. Marketed to older adults, the supplement boosts brain function to inhibit the symptoms of age-related cognitive decline, e.g., memory loss.

Memo Defend claims to eliminate degenerative brain conditions, improve memory recall, and support cognition, infused with high-powered natural ingredients.

The formula contains optimal dosages of all ingredients with 620 milligrams of its proprietary blend per serving.

Though the brain-boosting properties of the elements present in Memo Defend are not supported by ample scientific evidence, anecdotal evidence suggests that Memo Defend delivers good results.

Formulation Capsules
Ingredients Green tea, Juniper, Hibiscus, Hawthorn, Garlic, Olive, Buchu, Vitamin C, Niacin
Side effects No side effects
Price $69
Dosage 2 capsules daily
Money-back guarantee 60-day money-back guarantee

MemoSurge

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MemoSurge is another memory loss supplement that claims to repair nerve damage to reverse age-related cognitive impairment. The formula purportedly boosts your brain function in three steps, i.e., it strengthens neurotransmitters in your brain, nourishes and rejuvenates brain cells, and prevents brain shrinkage.

MemoSurge helps you regain old memories by repairing brain cell damage that is known to cause memory impairment. The formula helps eliminate mental problems like anxiety and insomnia, boosts your energy levels, and improves your attention and focus. MemoSurge comes with a few downsides like undisclosed ingredients and limited information to support the claims made by the manufacturer.

Formulation Capsules
Ingredients Phosphatidylserine, n-acetyl-l-carnitine, Bacopa monnieri extract, and St John’s wort
Side effects No side effects
Price $69
Dosage 1 capsule daily
Money-back guarantee 60-day money-back guarantee

Nootrogen

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Infused with 30 mind-boosting ingredients, Nootrogen helps support brain wellness while alleviating stress and anxiety. The supplement helps relieve symptoms of mild cognitive impairment, e.g., short-term memory loss and dementia. It enhances your brain performance by retaining neural pathways, restoring degenerative brain cells, and improving nerve signaling in the brain.

Nootrogen is one of the most reasonable supplements on the list. It has the edge over other supplements on the list due to its price-to-value ratio and premium quality standards. Nootrogen is manufactured in compliance with Good Manufacturing Practices in an FDA-registered facility and undergoes rigorous clinical testing making it one of the safest products on the list.

Formulation Capsules
Ingredients Bacopa extract, Glutamic acid, Phosphatidylserine, Dimethylethanolamine (DMAE), L-tyrosine, Magnesium, Vitamin B6, Vitamin B5, Vitamin B3
Side effects No side effects
Price $30
Dosage 2 capsules daily
Money-back guarantee 180-day money-back guarantee

PureHealth Research Ageless Brain

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Developed by PureHealth Research, Ageless Brain is a cognitive-enhancement supplement that helps you reclaim your memory capacity. Packed with powerful mind-boosting ingredients, the supplement boosts your energy levels and heightens your brain’s ability to focus.

Ageless Brain is formulated to boost neuromodulators, e.g., acetylcholine improves your intelligence level by enhancing your brain’s ability to concentrate. It also promotes healthy blood circulation in the brain to improve brain function and prevent brain shrinkage and age-related cognitive declines.

Formulation Capsules
Ingredients Gamma-aminobutyric acid (GABA), caffeine anhydrous, niacin, bacopa extract, alpha glycerylphosphorylcholine, l-theanine, green tea extract, huperzine-A, l-tyrosine, phosphatidylserine
Side effects No side effects
Price $44
Dosage 1 capsule daily
Money-back guarantee 365-day money-back guarantee

Organixx Ageless Brain

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We have two supplements on the list that are named “Ageless Brain.” The Ageless Brain nootropic supplement developed by Organixx is a bit pricey. The supplement contains brain-boosting organic ingredients that help supercharge your memory and improve brain function.

Manufactured in a cGMP facility, Ageless Brain by Organixx claims to reduce symptoms of cognitive impairment. The brain pill is formulated to support mental function in many ways, i.e., eliminates brain fog, helps maintain brain energy, improves mental focus, and promotes calm feelings. Infused with antioxidants, the formula present in Ageless Brain prevents oxidative cell damage in the brain, alleviates inflammation in the nervous tissue, and promotes undisrupted communication between neurons.

Formulation Capsules
Ingredients Dragon’s blood, camu camu, cacao, cinnamon, guayusa, and bacopa monnieri
Side effects No side effects
Price $55
Dosage 2 capsules daily
Money-back guarantee 365-day money-back guarantee

SANE Vitaae

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Developed by SANE, Vitaae is an anti-aging formula infused with essential vitamins and herbal extracts that boost brain function by reducing inflammation in brain tissue and reversing damage caused by free radicals. The supplement contains eight potent ingredients that work synergistically to improve memory, learning, focus, and other aspects of your mental function.

In older adults, Vitaae helps minimize age-related cognitive decline by preventing mental slips from progressing. In addition to improving brain function, Vitaae boosts your immune response to prevent your brain cells from future damage.

All ingredients present in Vitaae are safe, well-researched, and clinically studied. Vitaae comes with a one-year money-back guarantee.

Formulation Capsules
Ingredients Vitamin D, folate, citicoline sodium, coenzyme Q-10, and a 160mg proprietary blend called VitaalMind
Side effects No side effects
Price $47
Dosage 1 capsule daily
Money-back guarantee 365-day money-back guarantee

Onnit Alpha Brain

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Developed by Onnit, Alpha Brain is a dietary supplement that helps support memory, focus mental speed, and other aspects of your mental acuity. This brain pill is one of the most popular nootropic supplements available in the market to maximize mental and physical performance. Alpha Brain helps you achieve the best cognitive performance so that your brain responds to stimuli and processes things efficiently. The supplement is caffeine-free, nut-free, dairy-free, and gluten-free, which arguably makes it the best nootropic supplement sold online.

The supplement also contains proprietary blends with disclosed individual doses of most ingredients. Alpha Brain is one of the most budget-friendly supplements on the list.

Formulation Capsules
Ingredients Bacopa monnieri, oat straw, Huperzia Serrata, and Cat’s Claw
Side effects No side effects
Price $27
Dosage 1 capsule daily
Money-back guarantee 90-day money-back guarantee

Brain Boost

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Developed by Vital Plan, Brain Boost is a nootropic supplement that boosts your cognition to support memory, mental clarity, focus, and your brain’s processing speed. Additionally, it helps improve immunity, boost energy levels, and alleviate physical and psychological stress.

The ingredients help improve brain function while supporting other aspects of your overall body health, e.g., digestion. Some of these ingredients possess metabolism-boosting properties that promote healthy gut flora to enhance digestion and prevent gastrointestinal problems.

Designed by Dr. Bills Rawls, MD, Brain Boost contains no proprietary formulas. The supplement has transparent labeling with dosages of all ingredients disclosed, due to which it is deemed one of the best nootropic supplements of 2021.

Formulation Capsules
Ingredients Ginkgo Biloba, cat’s claw, lion’s mane mushroom, and bacopa monnieri
Side effects No side effects
Price $48
Dosage 4 capsules daily
Money-back guarantee 60-day money-back guarantee

Performance Lab Mind

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As the name suggests, Performance Lab Mind is an effective mind-boosting formula developed by Performance Lab. The supplement purportedly boosts your brain energy up to 13.6%. Additionally, the Performance Lab Mind helps alleviate symptoms associated with brain fog, i.e., confusion, poor concentration, lack of mental clarity, inability to focus, forgetfulness, low motivation, low energy, sleeping difficulties, and headaches.

The ingredients of Performance Lab Mind eliminate mental fatigue and help you recover from intense cognitive exertion. It contains powerful antioxidants, vitamins, and minerals required by your brain to function correctly.

Formulation Capsules
Ingredients Phosphatidylserine, L-tyrosine, Citicoline, Maritime pine bark extract
Side effects No side effects
Price $69
Dosage 1 capsule daily
Money-back guarantee 30-day money-back guarantee

Nuzena Neuro Focus +

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Developed by Nuzena, Neuro Focus + is a nootropic supplement that promotes optimal brain function. The supplement improves your brain performance by supporting your mental focus, memory recall, and cognitive function.

Neuro Focus + alleviates many types of cognitive dysfunction symptoms, e.g., mental fatigue or brain fog. Infused with potent antioxidants, the supplement repairs brain damage caused by free radicals. It dilates the arteries and veins present in the brain to increase blood circulation, thereby improving your brain’s uptake of oxygen and nutrients.

It is manufactured in an FDA-registered cGMP facility and is one of the safest nootropic supplements on the list containing 100% natural, well-researched, and clinically studied ingredients. The price per bottle drops if you purchase a 3-month supply.

Formulation Capsules
Ingredients Glutamic acid, Dimethylethanolamine (DMAE) bitartrate, Green tea extract, Bilberry fruit extract
Side effects No side effects
Price $30
Dosage 2 capsules daily
Money-back guarantee 100-day money-back guarantee

NooBru

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Introduced in 2020, NooBru is a dietary supplement designed to enhance your brain cell growth and brain performance. It comes in the form of powder and is marketed to older adults, students, and athletes to boost brain power and promote brain cell development.

Healthy brain function with slow cognitive decline is the main cognitive benefit offered by the supplement. Also, it promotes the nerve growth factor to better your cognitive functions and memory retention.

Formulation Powder
Ingredients Phosphatidylserine, CDP choline, n-acetyl l-tyrosine, absorbagen, sulbutiamine, and huperzine A, alpha GPC, l-theanine, ashwagandha, vitamin B6, and vitamin B5.
Side effects No side effects
Price $55
Dosage 1 sachet daily
Money-back guarantee 67-day money-back guarantee

Hunter Focus

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Developed by Roar Ambition, Hunter Focus is a nootropic supplement formulated with all-natural, high-quality ingredients that enhance your cognitive function.

Hunter Focus is marketed as an intelligent solution designed to eliminate brain fog. The supplement is one of the most widely recommended nootropics due to its ingredient transparency. Being one of the top nootropics and smart drugs, this brain pill aims to strengthen your brain pathways to improve mental performance.

Formulation Capsules
Ingredients Passionflower, Phosphatidylserine, Bacopa monnieri
Side effects No side effects
Price $60
Dosage 4 capsules daily
Money-back guarantee 90-day money-back guarantee

BrainPill

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Infused with 13 natural nootropics, BrainPill is a brain-boosting nutritional supplement formulated to enhance your cognitive function. The supplement is marketed as an “unfair advantage” over other nootropic supplements. It claims to support your brain performance by boosting your working memory, eliminating mental fog, promoting mental clarity, increasing cognitive energy, improving your ability to concentrate, and enhancing recall.

Doctors like Dr. Dave David widely recommend BrainPill. Unlike other supplements, BrainPill contains a caffeine-free formula that doesn’t rely on central nervous system (CNS) stimulants to improve mental alertness. It keeps your brain active all day long without giving it high doses of psychoactive substances.

BrainPill is a high-quality cognitive-enhancer containing proper doses of all active ingredients present in it as marketed by its manufacturer.

Formulation Capsules
Ingredients Caffeine, tyrosine, l-theanine, citicoline, and vitamin B12
Side effects No side effects
Price $69
Dosage 2 capsules daily
Money-back guarantee 60-day money-back guarantee

OptiMind

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Infused with bacosides, OptiMind is a nutritional supplement designed to improve your cognitive health, memory, focus, and other aspects. It boosts your mental energy and helps you achieve greater mental clarity. The primary ingredient present in the supplement is bacopa monnieri with 55% bacosides, compounds that help boost serotonin levels.

Due to its bacoside-rich content, OptiMind keeps your mind alert and energetic by boosting serotonin production, regulating serotonin reuptake, and increasing the intensity and duration of its activity at neuronal junctions. The supplement uses clinically studied ingredients that alter the levels of neurotransmitters to boost brain function.

Formulation Capsules
Ingredients Bacopa monnieri ,l-taurine, phosphatidylserine, synapsa, alpha-lipoic acid, t-tyrosine, and gamma-aminobutyric acid (GABA)
Side effects No side effects
Price $30
Dosage 1 capsule daily
Money-back guarantee 60-day money-back guarantee

Youthful Brain

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Developed by Vitality Now, Youthful Brain is a dietary supplement that helps improve your brain performance by boosting your mental energy, cognition, and overall brain energy. It uses a powerful blend of active ingredients to improve mental functions such as creativity, memory, attention, and motivation.

Youthful Brain contains virtually the same ingredients as other supplements on the list. However, the elements are present in relatively low doses.

Formulation Tablets
Ingredients Bacopa monnieri, huperzine A, vitamin B12
Side effects No side effects
Price $65
Dosage 2 tablets daily
Money-back guarantee 60-day money-back guarantee

Mind & Mood

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Developed by UpWellness, Mind & Mood is a nutritional supplement that acts both as a nootropic and mood-enhancer. Unlike most brain health supplements, Mind & Mood helps improve your emotional health while supporting your cognitive health. Replete with adaptogenic ingredients, it calms your nervous system to alleviate anxiety, stress, and episodes of depression.

The formula is designed by Dr. Amanda Levitt and Dr. Joshua Levitt and is one of the few supplements on the list created by real doctors.

Formulation Capsules
Ingredients 5-HTP, gamma-aminobutyric acid (GABA), Rhodiola Rosea extract, l-theanine, and saffron
Side effects No side effects
Price $57
Dosage 2 capsules daily
Money-back guarantee 30-day money-back guarantee

BrainEssence

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Developed by PureEssence, BrainEssence is a brain supplement that helps eliminate memory problems, improves your ability to concentrate, and gives you greater mental clarity. The supplement supports your cognitive health-supporting brain plasticity, i.e., boosts brain energy, etc.

Formulation Tablets
Ingredients Bacopa monnieri extract, ashwagandha, Rhodiola Rosea, alpha-lipoic acid, Chinese club moss extract, and acetyl l-carnitine
Side effects No side effects
Price $30
Dosage 2 tablets daily
Money-back guarantee 60-day money-back guarantee

Elm & Rye Nootropics

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A brain health supplement offered by Elm and Rye, Nootropics is formulated to improve your cognitive function, specifically executive functions, i.e., memory, creativity, motivation, etc. Infused with a high dose of caffeine, the supplement provides you with long-lasting energy boosts that help increase your productivity. The quantity of caffeine per serving of this supplement is equivalent to 2 to 3 cups of coffee at once.

Formulation Tablets
Ingredients Phosphatidylserine, gamma-aminobutyric acid, bacopa monnieri extract, alpha GPC, l-tyrosine, l-theanine, and B vitamins
Side effects No side effects
Price $85
Dosage 2 tablets daily
Money-back guarantee 30-day money-back guarantee

Memory Hack

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Created by Nutrition Hacks, Memory Hack is a dietary supplement that acts as a cognitive enhancer. The supplement is designed to improve the three major processes involved in memory, i.e., encoding, storage, and retrieval. It helps alleviate symptoms of many memory disorders, e.g., dementia, mild cognitive impairment, amnesia, etc.

Though Memory Hack helps improve memory retention, in the long run, it doesn’t deliver results overnight. The supplement should not be relied upon for total restoration of memory. It’s a mild nootropic that helps slow down age-related cognitive power decline.

Formulation Capsules
Ingredients L-theanine, choline, Ginkgo Biloba, and St. John’s worst
Side effects No side effects
Price $69
Dosage 2 capsules daily
Money-back guarantee 60-day money-back guarantee

Cymbiotika Golden Mind

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Developed by Cymbiotika, Golden Mind is a brain-enhancing dietary supplement that comes in liquid form. The supplement contains mind-boosting ingredients.

Golden Mind boosts your brain function by promoting blood circulation in the brain tissue. The supplement is infused with ingredients that stimulate cell production in the brain and nourish the existing brain cells.

Formulation Oil
Ingredients Lion’s mane, Rhodiola Rosea, l-theanine, Gotu kola extract, sea buckthorn oil, phosphatidylserine, and a blend of 82 ocean minerals
Side effects No side effects
Price $50
Dosage 14 drops daily
Money-back guarantee 30-day money-back guarantee

Amy Myers MD NeuroLive

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NeuroLive is a nootropic nutritional supplement formulated by Amy Myers, MD. NeuroLive is replete with antioxidants that protect your brain from damage by free radicals. The supplement is designed to maintain your memory and thinking ability by promoting a healthy balance of neurotransmitters in your brain.

It supports your brain function by boosting blood circulation in the brain. It also produces calming effects, thereby helping alleviate stress and anxiety.

Formulation Capsules
Ingredients Mucuna pruriens seed extract, phosphatidylserine (as Sharp•PS® GREEN), l-theanine, vitamin B6, bacopa monnieri, and Ginkgo Biloba leaf extract
Side effects No side effects
Price $50
Dosage 2 capsules daily
Money-back guarantee 90-day money-back guarantee

ReMind Solution

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ReMind or ReMind Solution is an advanced cognitive enhancer designed to improve memory, focus, thinking ability, and overall brain function. Infused with powerful antioxidants, the supplement helps your brain tissue recover from oxidative damage caused by free radicals. It also boosts the flow of blood and oxygen to brain tissue, thereby nourishing brain cells.

ReMind is one of the most expensive supplements on the list. Though ReMind comes with a premium price tag, it provides few advantages over other nootropics falling in the same price range.

Formulation Capsules
Ingredients Huperzine A, Vinpocetine, St. John’s wort, N-acetyl l-carnitine, Ginkgo Biloba extract, L-glutamine, Phosphatidylserine
Side effects No side effects
Price $69
Dosage 1 capsule daily
Money-back guarantee 60-day money-back guarantee

Oweli Neuro

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Developed by Oweli, Neuro Brain & Focus is a brain-enhancing supplement that supports your cognitive health and fights age-related cognitive impairment. The supplement claims to unleash 100% of your brain’s potential.

Neuro improves your cognitive health by supporting neuroplasticity, i.e., your brain’s ability to change through growth and reorganization. Neuro claims to deliver life-changing results by enabling your brain to work at 100% capacity. If you find yourself unable to focus on tasks, you can use this nootropic formula to have zen-like focus and multitasking ability. Neuro is very competitively priced as well.

Formulation Capsules
Ingredients B vitamins, Dimethylethanolamine (DMAE), Inositol, Phosphatidylserine, Huperzine A, Bacopa monnieri extract
Side effects No side effects
Price $30
Dosage 2 capsules daily
Money-back guarantee 100-day money-back guarantee

ProMind Complex

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Created by Carl Henderson, ProMind Complex is a nootropic formula that helps boost your cognitive abilities, i.e., brain-based skills you need to perform simple and complex tasks. Henderson has used his decades of experience to design an effective mind-boosting supplement that boosts your mental ability to reason, plan, comprehend, think, learn, and solve problems.

Although the supplement is replete with brain-enhancing elements, the dosage for each ingredient is incredibly low. ProMind is one of the most high-priced supplements on the list.

Formulation Capsules
Ingredients Huperzine A, L-glutamine, Phosphatidylserine, Vinpocetine, Bacopa monnieri extract
Side effects No side effects
Price $69
Dosage 2 capsules daily
Money-back guarantee 60-day money-back guarantee

NeuroGum

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NeuroGum is the only nootropic supplement on the list that comes in the form of gums. It is a sugar-free energy gum that comes in mint and cinnamon flavors. Neurogum is formulated with powerful nootropics that work in synergy to boost your mental energy, improve your focus, and give you greater mental clarity. Each gum is packed with a potent blend of mind-boosting ingredients.

NeuroGum uses a patented cold compression system to maximize the bioavailability and absorption of ingredients present in it.

Formulation Gummies
Ingredients Caffeine, l-theanine, and B vitamins
Side effects No side effects
Price $21
Dosage 1 gummy daily
Money-back guarantee 30-day money-back guarantee

Qualia Mind

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Developed by Neurohacker Collective, Qualia Mind is a brain-boosting nutritional supplement that supports your cognitive function and ensures long-term mental performance. Neurohacker Collective offers four dietary supplements, i.e., Qualia Mind, Qualia Mind Essentials, Qualia Focus, and Qualia Mind Caffeine.

Qualia Mind is infused with 28 powerful ingredients that work synergistically to offer cognitive benefits and improve mental performance, unlike other cognitive enhancers.

Formulation Capsules
Ingredients Ginkgo Biloba, alpha GPC, bacopa monnieri, Celastrus paniculatus, DHA
Side effects No side effects
Price $59
Dosage Seven capsules daily
Money-back guarantee 100-day money-back guarantee

NeuroActiv6

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Developed by NaturalCell, NeuroActiv6 is a cognitive-enhancement formula that helps enhance cognitive performance by improving your memory, focus, and attention. The formula comes in powdered form and can be mixed with the beverage of your choice. It promotes healthy brain functioning by preventing oxidative cell damage, promoting neural communication, and increasing blood flow to the brain tissue.

Formulation Powder
Ingredients B vitamins, citicoline, ashwagandha, turmeric, coffee fruit extract, and grape seed extract
Side effects No side effects
Price $46
Dosage One scoop daily
Money-back guarantee 60-day money-back guarantee

Synapse XT

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As a nootropic supplement, Synapse XT supports both mental processing speed and hearing ability. Marketed to older adults, this brain pill is a nutritional supplement that treats all symptoms of age-induced cognitive decline, i.e., forgetfulness, impaired hearing ability, confusion, etc. The brain pill contains a powerful blend of vitamins, minerals, plant extracts, and herbs that work in synergy to minimize signs of brain fatigue.

Regular intake of this nootropic supplement helps improve memory, hearing, and ability to focus in older adults. The supplement is loaded with ingredients that help boost activity on neuronal junctions, thereby supporting communication between brain cells.

Formulation Capsules
Ingredients Hibiscus, Garlic, Vitamin-B, Hawthorn Berry, Potassium, Roseberry, Magnesium, Green tea
Side effects No side effects
Price $69
Dosage 2 capsules daily
Money-back guarantee 60-day money-back guarantee

NooCube Brain Productivity

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Developed by neuroscientists, NooCube Brain Productivity uses all-natural ingredients to support your cognition and memory retention. It is a caffeine-free dietary supplement that helps alleviate the symptoms of all types of cognitive dysfunctions.

By balancing the levels of brain chemicals, this nootropic supplement improves your mental performance and mental processing speed. Also, it helps generate new brain cells to boost memory and cognitive abilities. Being backed by a 60-day money-back guarantee, this supplement is a safe choice as well.

Formulation Capsules
Ingredients Huperzine A, Alpha GPC, bacopa monnieri, and Cat’s Claw extract
Side effects No side effects
Price $60
Dosage 2 capsules daily
Money-back guarantee 60-day money-back guarantee

NeuroFuel

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Developed by Natural Stacks, NeuroFuel is a nootropic supplement that helps optimize brain health and improves cognitive function. This brain pill is the only “open source” supplement on the list as it traced all ingredients and sources on the blockchain. It uses unique ingredients like artichoke extract to promote better brain cell regeneration.

The supplement includes minimal ingredients with substantial doses, making it one of the most effective nootropics for increasing brain power.

Formulation Capsules
Ingredients L-carnitine, vitamin B6, and l-phenylaniline that add to the effects of artichoke leaf extract
Side effects No side effects
Price $30
Dosage 1 capsule daily
Money-back guarantee 30-day money-back guarantee

CogniBiotics

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CogniBiotics is a brain health supplement that contains a powerful blend of natural ingredients that work in synergy to improve brain health and eliminate mental fatigue. It is formulated to address cognitive impairment associated with poor gut health. It targets your brain by optimizing digestion and that’s why it must be included in your nootropic stack.

Infused with 17 stress-alleviating and brain-boosting herbs, CogniBiotics improves your gut microbiota to boost your cognitive function. The supplement also comes with brain-friendly probiotic strains that help promote healthy bacteria levels in your digestive tract.

Formulation Capsules
Ingredients Proprietary probiotic blend, Prebiotic complex, Chinese herbal brand
Side effects No side effects
Price $62
Dosage 2 capsules daily
Money-back guarantee 365-day money-back guarantee

How Did We Rank The Best Nootropic Supplements?

Though all nootropics supplements make similar promises, only the best ones live up to their word. After perusing lab reports, clinical studies, research papers, and customer reviews, our editorial team came up with the best nootropic supplements available in the market. Our editorial team took the following factors into account while compiling the list:

Advertised Mental Benefits

In 2019, the U.S. Food and Drug Administration warned the public regarding marketing frauds and advertising scams related to nootropic supplements. Our editorial team was particularly wary of companies that make unrealistic claims about their products. There are no supplements on the list that exaggerate their usefulness by promising to supercharge your brain overnight. We only included products from companies that are honest and transparent in their advertising.

Scientifically-proven Ingredients

We preferred nootropic supplements with scientifically proven natural nootropic ingredients over supplements that contain filler ingredients with no scientific backing. All nootropic supplements on the list contain plant and herbal extracts whose effectiveness in boosting brain health has been supported by scientific evidence. All supplements included in the list contain well-researched, clinically-studied, and scientifically proven ingredients.

Safe & Effective Dosages

All supplements included in our list contain the right ingredients with the dosages. The effectiveness of a nootropic formula depends very much on the number of elements present. At times, too much or too little of an ingredient might render the entire formula ineffective.

Transparency

Most nootropic supplements available in the market conceal weak dosages and filler ingredients under proprietary blends. In the supplement space, many companies cause you to believe that their product contains unique brain-boosting ingredients – when all you’re getting is 300 milligrams of caffeine hidden within a 350mg proprietary blend. Our editorial team was specifically wary of companies that do not disclose full ingredient labels or hide doses under proprietary blends.

Anecdotal & Empirical Evidence

At times, even the best nootropic supplements fail to yield results. What works for one person may not work for the other. Therefore, we took customer reviews and subjective experiences into account while compiling the list. At times, the supplements that are not backed by ample scientific research turn out to be most effective.

Formula Development

While real doctors formulate some nootropic supplements, some are merely designed by marketers. All supplements included in our list are either developed by doctors or contain formulas designed under the consultation of a medical advisory board.

Clinical Testing

As clinical trials are expensive and require time, most companies do not invest in them. Most of the supplements included in our list are offered by companies that invest in clinical trials and peer-reviewed research. Some companies pay third-party labs to test the effectiveness of their formulas.

The Reputation of the Manufacturer

All products on our list are offered by highly credible manufacturers known for creating high-quality, effective formulas. The age of the company did not merely determine the reputation of the manufacturers.

Price & Value

Though some people might want to spend $100 per month on nootropic supplements, some are looking for inexpensive ways to boost cognitive function. Therefore, our list includes products belonging to different price ranges. However, all products are safe and offer good value regardless of their price.

Refund Policy

While compiling the list, our editorial team preferred products that come with a satisfaction guarantee and refund policy. Most, if not all, supplements on our list come with a money-back guarantee.

Scientific Evidence Related To Nootropic Supplements

A tremendous amount of scientific evidence is available that corroborates the effectiveness of natural nootropics in supporting healthy brain cells. Most of the ingredients present in the natural nootropics on your list are backed by decades of scientific research.

Bacopa monnieri is one of the most well-researched and clinically-tested ingredients present in brain health supplements. It has been used in Chinese folk medicine and Ayurvedic (traditional Indian) medicine for centuries.

According to a study conducted in 2001, bacopa monnieri may enhance higher-order cognitive processes if administered for a prolonged period, e.g., three months. Researchers found that the herbal extract was specifically effective at improving executive function, i.e., memory, creativity, motivation, etc, and balancing brain chemicals.

Another study conducted in 2008 concluded that regular administration of 300mg of bacopa monnieri could help inhibit cognitive impairment in older adults. Today, the efficacy of bacosides, compounds isolated from Bacopa monnieri, is supported by zillions of clinical trials and studies.

Like bacopa monnieri, Ginkgo Biloba has also been used for centuries in traditional Chinese medicine. Both anecdotal evidence and scientific research verify its effectiveness as a brain enhancer. In a study conducted in 2001, participants were given a blend of Ginkgo Biloba and vinpocetine regularly for two weeks.

After two weeks, researchers observed a noticeable improvement in mental performance, e.g., improved memory in more than half participants.

Similarly, the mind-boosting and adaptogenic properties of ashwagandha have been corroborated by ample scientific research. The herb contains powerful antioxidants that fight off neurotoxins present in the brain. The mind-protecting compounds present in ashwagandha help impede cognitive ability decline induced by the process of aging.

Other ingredients present in nootropic supplements that have been extensively studied include huperzine A, l-theanine, Panax ginseng, and caffeine. Huperzine A acts as a cholinesterase inhibitor to boost healthy levels of neurotransmitters in the brain.

Some studies suggest that it might help impede the cognitive impairment associated with Alzheimer’s. Similarly, l-theanine and caffeine are extensively studied and tested for their brain-boosting properties. Both ingredients have been proven to support brain function in many ways, i.e., promote gray matter formation, adjust neural pathways, and boost brain electrical activity.

Nootropics Side Effects

The likelihood of side effects is rare in healthy adults if the administration is carried according to the recommended dosage. Nevertheless, some people may experience minor side effects like nausea, headaches, and digestive discomfort. People who do not have any underlying health conditions are unlikely to experience any kind of side effects.

Nootropic supplements containing central nervous system (CNS) stimulants, i.e., caffeine, may cause side effects like anxiety, nausea, chest tightness, and jitters if administered at high doses.

Some people may experience allergic reactions to certain ingredients present in the supplement. For example, bacopa monnieri may cause an allergic reaction in your gastrointestinal tract. Typically, the side effects go away in a few weeks. However, if you experience severe and persistent side effects, you should immediately cease use and consult a doctor.

Frequently Asked Questions About Nootropics

We get zillions of questions regarding nootropics daily. Here are some of the most frequently asked questions about nootropics and the role they play in your brain functioning:

Q: What are nootropics?

A: Nootropics are a class of substances, e.g., drugs and supplements that claim to support your cognitive functions and boost your brain performance.

Q: What do nootropics do?

A: Nootropics support long-term brain health, memory retention, and improve your brain performance in a myriad of ways. Some nootropics act as stimulants to keep you mentally alert. Others boost memory and impede age-related cognitive power decline.

Q: Where can I take a nootropic?

A: You can buy a nootropic supplement online from Amazon or other major retailers. The recommended dosage for most nootropic supplements is one or two capsules a day with a glass of water. You must call your doctor before taking the supplement.

Q: What does “nootropic” mean?

A: “Nootropic” is a term coined by Dr. Corneliu E. Giurgea, a Roman psychologist in the 1970s. Dr. Giurgea combined three Greek words, i.e., noos (intelligence), vouc (Mind), and trope (turning), to form the word “nootropic,” which roughly translates into mind-turner.

Q: Are nootropics legal?

A: Yes, nootropics are legal in all 50 states of America. It’s legal to buy, possess, and consume nootropic supplements containing ingredients approved by the FDA. Most nootropics are neither controlled nor scheduled by the state.

Q: Are nootropics and smart drugs safe?

A: Nootropics are generally considered safe as most nootropic supplements contain ingredients Generally Recognized As Safe (GRAS) by the FDA. If you follow the recommended dosage instructions, you’re unlikely to experience any side effects or safety issues. Smart drugs only become unsafe when not administered according to the instructions, i.e., combined with drugs experimented with dosages, etc. If you have an underlying medical condition, you can affect your health adversely by taking nootropics.

Q: Do nootropics cause side effects?

A: Most of the best nootropic supplements are generally safe and do not cause any side effects. However, some people may experience minor side effects, e.g., nausea, headaches, jitters, and digestive issues in rare cases.

Q: Who are smart drugs marketed to?

A: Smart drugs are marketed to older adults, students over 18, athletes, and people looking to have a cognitive edge over their competitors.

Q: Are all nootropic supplements made from natural ingredients?

A: Though most nootropic supplements contain 100% natural ingredients, i.e., vitamins, minerals, herbs, and plant extracts, some may include synthetic compounds. You should check the ingredients label before buying.

Q: Are nootropic supplements vegan?

A: Yes, almost all nootropic formulas that come in powdered or liquid form are vegan. However, supplements that come in the form of capsules contain gelatin made from beef or pork.

Q: Can nootropic supplements cause dependence?

A: Generally, nootropics supplements are not considered addictive. However, some nootropic supplements contain ingredients that have the potential for addiction or dependence.

Q: Do I need a prescription to buy nootropic supplements?

A: When it comes to buying nutritional supplements, you do not need a prescription. You only need a prescription to purchase nootropic drugs, e.g., modafinil (Provigil). However, you must talk to the doctor before taking any nootropic supplement.

Q: Can nootropic supplements help treat Alzheimer’s?

A: Nootropic supplements are not meant to treat cognitive disorders. However, they may help alleviate the symptoms associated with dementia and other types of cognitive dysfunction. For a progressive neurological disease like Alzheimer’s, you should take prescription nootropic drugs instead of nutritional supplements. You must talk to your doctor before taking any nootropic.

Q: When should I take nootropics?

A: Nootropics or smart drugs should be taken in the morning or early afternoon to boost your stamina and productivity during regular working hours. If the supplement you’re taking contains a central nervous system (CNS) stimulant, e.g., caffeine, you should avoid taking it in the evening or late at night to prevent disruptions in your sleeping cycle.

The Top 33 Nootropic Brain Booster Supplements Conclusion

Nootropics or smart drugs have become very popular in the supplement space. From senior citizens to college students, everyone is taking smart drugs to improve cognitive function. There are zillions of nootropic supplements available in the market that help boost brain performance and support all aspects of your mental health. Try one of the 33 top nootropic supplements today!

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Disclaimer:

Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.

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